Intro
Before you set the tile, test the layout. You should have full tiles in the field of the site and as few cut tiles as possible on the edges.
Snap chalk lines between the midpoints of each side. If your slab has a control joint, snap chalk lines between the midpoints of the sides parallel to the control joint. Starting at the center point or the junction of the chalk line and control joint, dry-lay tiles and spacers on both axes, extending the tiles to the edge of the slab.
If one side ends with a full tile and the opposite side has only a partial tile, move the chalk line so both sides will have tiles of the same size. Adjust the tiles on both chalk lines but not on the control joint. When the layout fits the slab, snap reference lines at intervals equal to the tile dimensions.
Ideally you should apply mortar when the temperature is 60 to 70 degrees F. Don't work in direct sunlight; the mortar will set up too quickly. Start with enough mortar to lay just a few tiles. Work in sections you can complete in 10 minutes. As you set the tiles, mortar will squeeze up between them. If the mortar is more than half the tile thickness, you're using too much.
Checklist
Time
18 to 24 hours for a 10x10-foot area
Tools
Five-gallon bucket, 1/2-inch drill, mixing paddle, chalk line, snap cutter or wet saw, square-notched trowel, beater block, rubber mallet, straightedge, grout float, caulk gun, wide putty knife, nippers, grout bag, sponge
Skills
Mixing mortar; setting, cutting, and grouting tile
Prep
Repair existing slab or install a new one
Materials
Latex-modified thinset, grout, tile, foam backer rod, caulk, spacers, sealers